In 2008, roughly 14.3 million Americans were taking antipsychotics for behavioral disorders, making them among the most prescribed drugs in the US. Almost all of these medications are known to cause metabolic side effects such as obesity and diabetes. In a paper published Jan. 31 in the journal Molecular Psychiatry, researchers at Sanford-Burnham Medical Research Institute reveal how antipsychotic drugs interfere with normal metabolism by activating a protein called SMAD3, an important part of the transforming growth factor beta pathway.

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